
Mission
To redefine in vivo gene editing by delivering functional genome editing machinery directly to the tissues.
Incisive Genetics is advancing a new class of non-viral gene editing therapeutics designed to address diseases at their genetic origin. Our work is built on decades of Huntington’s disease (HD) research and powered by proprietary in vivo delivery technology. All with the goal of bringing precision gene editing from the lab to the patients who need it.

To redefine in vivo gene editing by delivering functional genome editing machinery directly to the tissues.

A future where devastating genetic diseases are treated at their source in a safe, durable manner before irreversible damage occurs.
Incisive Genetics was founded as a spinout from the University of British Columbia’s Centre for Molecular Medicine and Therapeutics.
Our origins are deeply rooted in Huntington’s disease research. For more than two decades, our scientific leadership has studied the genetics, pathogenesis, and clinical progression of HD. While the causative mutation has been known for years, delivering gene editing safely and effectively inside the human body remains a major hurdle.
We recognized that the future of gene editing would depend not only on powerful editing enzymes, but on the ability to deliver them in their active form.
This insight led to the development of our proprietary lipid nanoparticle platform capable of encapsulating and delivering pre-formed ribonucleoprotein (RNP) complexes in vivo.

Our leadership team brings deep expertise across neurology, gene editing, clinical development, and operational execution that positions the company to advance from preclinical development into human trials.
We are building a company defined by precision science, clinical execution, and an unwavering commitment to patients.

Incisive Genetics is advancing IG-HD01 toward clinical development while continuing to expand the potential applications of our proprietary delivery platform.